Senior Scientist, Vector Process & Analytical Development

Job title: Senior Scientist, Vector Process & Analytical Development

Company: Adaptimmune

Job description: Adaptimmune is a fully integrated cell therapy company, designed and built from the ground up with four U.K.- and U.S.-based biotechnology hub locations. Our comprehensive capabilities and teams include preclinical research, clinical development, translational sciences, autologous and allogeneic manufacturing, and in-house commercial and corporate operations.Our company culture is rooted in trust, inclusion, our capacity to collaborate, and our commitment to being honest and brave in our desire to successfully transform the lives of people with cancer.PRIMARY RESPONSIBILITYThe Vector Process & Analytical Development team is focused on the development of Adaptimmune’s Lentiviral Vector manufacturing process, and the development and qualification of analytical assays used for Lentiviral Vector characterisation and release. The purpose of this role is to support the Vector Analytical Development function.The role requires the job holder to design and execute Analytical Development projects to advance our understanding of Adaptimmune’s lentiviral vector products and will involve running of analytical assays to support company objectives. The Senior Scientist will be mostly independent in experimental planning and execution, analysis and interpretation, but may still require scientific guidance at some level from senior colleagues (Group Leader/Principal Scientists). The job holder is expected to work cross functionally within matrixed project teams by collaborating with other departments (e.g. Vector PD, Autologous PD and AD, QC, MSAT and manufacturing) to support company objectives.Although this role is predominantly lab-based, depending on the requirement, availability and appropriateness, individuals in the Senior Scientist role may be involved in project work-stream leadership/management and/or supervision of other junior scientists, paving way for career progression.KEY RESPONSIBILITIESThe Senior Scientist is expected to:

• plan, design, conduct, analyse and interpret experiments mostly independently
• take ownership for the quality of assay performance and ongoing maintenance in the context of the project and study aims

Experiments are fully and accurately recorded to ensure data traceability, including:

• maintaining databases
• results fully analysed and written up in Electronic Laboratory Notebooks (ELN) in a timely manner
• Participate in group and project meetings and discussions.
• Contribute to routine lab maintenance

As required:

• project work-stream leadership/management
• supervision of other junior scientists

QUALIFICATIONS & EXPERIENCERequired

• Degree in Life Sciences, or related discipline.
• Substantial and relevant post-graduate experience, preferably in an industry setting.
• Experience of viral vector analytics & analytical development.
• Ability to work independently on routine experiments.
• Ability to learn and develop in order to work independently on complex experiments within a reasonable time frame.

Desirable

• Specific knowledge of lentiviral manufacture and analytics
• Experience of Tech Transferring assays to third parties
• Practical experience of working to GMP requirements
• Experience of preparing documents for regulatory submissions

At Adaptimmune we embrace diversity and equality of opportunity. We believe that the more inclusive we are, the better our work will be. We welcome applications to join our team from all qualified candidates, regardless of age, colour, disability, marital status, national origin, race, religion, gender, sexual orientation, gender identity, veteran status or other legally protected category. It is our intent that all qualified applicants will receive equal consideration for employment.

Expected salary:

Location: Abingdon, Oxfordshire

Job date: Sat, 19 Oct 2024 07:25:59 GMT

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